Chlorine dioxide has been shown to impair thyroid function and reduce CD4+ count in grivet monkeys after 6 months.


Bercz JP, Jones L, Garner L, Murray D, Ludwig DA, Boston J (2010-02-25). "Subchronic toxicity of chlorine dioxide and related compounds in drinking water in the nonhuman primate". Environ. Health Perspect. 46: 47–55. doi:10.1289/ehp.824647. PMC 1569048 PMID 7151767.

Full text:

Samenvatting: Subchronic toxicities of ClO2, NaClO2, NaClO3 and NH2Cl were studied in the African Green monkeys (Cercopithecus aethiops).

The chemicals were administered in drinking water during 30-60 days subchronic rising dose protocols. The only unexpected and significant toxic effect was elicited by ClO2; this chemical inhibited thyroid metabolism in the animals at a dose of ca. 9.0 mg/kg/day. A statistically significant decrease of serum thyroxine occurred after the fourth week of exposure to 100 mg/l.concentration. The extent of thyroid suppression was dose dependent in each individual monkey, and was reversible after cessation of exposure. NaClO2 and NaClO3 failed to elicit similar effects in doses up to ca. 60 mg/kg/day. Also, NaClO4 or NH2Cl did not cause T-4 suppression in doses of 10 mg/kg/day. The selective thyroid effect of ClO2 was unexplained and it appeared to be paradoxical since ClO2 was rapidly reduced by the oral and gastric secretions to nonoxidizing species (presumably Cl-). No evidence of thyroid effects were detected in the serum of human volunteers who ingested approximately 1 mg/l. of ClO2 in drinking water as a result of routine use in the community water treatment process. Sodium chlorite induced dose-dependent oxidative stress on hematopoesis, causing decreased hemoglobin and red cell count and increased methemoglobin content. At the same time, serum transaminase (SGPT) levels showed significant subclinical elevation. The hematologic effects of NaClO2 rebounded during exposure indicating compensatory hemopoietic activity taking effect during oxidative stress. Sodium chlorate and chloramine did not induce detectable hematologic changes in the animals.


Commentaar  Niet van toepassing!

  • 9.0 mg/kg/day is gelijk aan de concentratie zoals éénmalig gebruikt bij het experiment in Uganda bij volwassenen.
  • Echter: de apen ontvingen deze concentratie gedurende 30 tot 60 dagen. Dit onderzoek verschaft geen bruikbaar inzicht voor de MMS-toepassing. Maar dit onderzoek heeft, zoals beschreven op wikipedia, wel bijgedragen aan de ondermijning van ClO2 als potentieel geneesmiddel.
  • Dit onderzoek werd aangehaald op verschillende websites. Daar waar de ene website het presenteert alsof het gaat om een onderzoek naar de gevolgen van het binnenkrijgen van chlorine dioxide, laat de andere website duidelijk ziet dat het gaat om de chlorieten die ontstaan als gevolg van het toevoegen van clo2 aan drinkwater.:
    • FOUT: Subchronic toxicity of chlorine dioxide was studied in the African green monkey
    • GOED: Subchronic toxicities of ClO2, NaClO2, NaClO3 and NH2Cl were studied in the African Green monkeys