/LABORATORY ANIMALS: Acute Exposure/ Groups of five male Sprague-Dawley rats received approximately 0, 0.12, 0.24, or 0.48 mg aqueous chlorine dioxide/kg body weight by oral gavage. Samples of blood were taken at 15, 30, 60, and 120 minutes post-administration for analysis of glutathione and methemoglobin levels and osmotic fragility; methemoglobin formation was not observed, and the other parameters measured were only slightly affected, with no clear dose-response relationship.

Bron: International Programme on Chemical Safety's Concise International Chemical Assessment Documents Number 37: Chlorine dioxide (2002). Available from, as of December 13, 2017: http://www.inchem.org/pages/cicads.html

Commentaar CLO2.nl: Niet van toepassing!

• slechts 0.48 mg/kg body weight, dat is veel te weinig om te kunnen concluderen dat het MMS protocol veilig is.
• methemoglobin formation was not observed (hieruit kun je concluderen dat orale inname van een lage dosis ClO2 niet leid tot meetbare methemoglobin formation)