WHO, World Health Organisation: https://www.who.int/ipcs/publications/cicad/en/cicad37.pdf: (Tekst kan vertalingsfouten bevatten.) In deze studie werd een chloordioxide-oplossing (UC-1) samengesteld uit chloordioxide geproduceerd met een elektrolytische methode. en vervolgens gezuiverd met een membraan. Van UC-1 werd vastgesteld dat het 2000 ppm chloordioxidegas in water bevat. De werkzaamheid en veiligheid van UC-1 werden geëvalueerd. Antimicrobiële activiteit was met meer dan 98,2% verminderd wanneer UC-1-concentraties respectievelijk 5 en 20 ppm waren voor bacteriën en schimmels. De maximale gemiddelde remmingsconcentraties (IC50) van H1N1, influenzavirus B / TW / 71718/04 en EV71 waren respectievelijk 84,65 0,64, 95,91 11,61 en 46,39 1,97 ppm. 3- (4,5-dimethylthiazol-2-yl) -2,5-difenyltetrazoliumbromide (MTT) onthulde dat de levensvatbaarheid van de cellen van muizenlongfibroblast L929-cellen 93,7% bij 200 ppm was. UC-1-concentratie hoger dan verwacht bij routinematig gebruik. Bovendien vertoonde de UC-1 van 50 ppm geen significante symptomen in een oogirritatietest bij konijnen. In een toxiciteitstest bij inademing toonde behandeling met 20 ppm UC-1 gedurende 24 uur geen abnormaliteit of mortaliteit bij abnormale klinische symptomen.
Functioneren van de longen en andere organen. Een ClO2-concentratie tot 40 ppm in drinkwater bleek geen toxiciteit te vertonen in een subchronische orale toxiciteitstest.
UC-1 vertoonde een gunstige desinfectie en een trend naar een hoger veiligheidsprofiel dan in eerdere rapporten.- https://arxiv.org/ftp/arxiv/papers/1304/1304.5163.pdf: ClO2, the so-called “ideal biocide”, could also be applied as an antiseptic if it was understood
why the solution’s rapid killing of microbes does not cause any harm to humans or to animals.
Our aim was to study both theoretically and experimentally its reaction-diffusion mechanism to
find the source of that selectivity.
Conclusion: Selectivity of ClO2 between humans and bacteria is based not on their different biochemistry, but
on their different size. Preliminary clinical results encourage further research with this promising
local antiseptic. - https://benthamopen.com/contents/pdf/TOANTIMJ/TOANTIMJ-2-71.pdf: Antiviral Effect of Chlorine Dioxide against Influenza Virus and Its
Application for Infection Control
Chlorine dioxide (ClO2) has a strong antiviral effect, and can disinfect the surface of object and the air in space. In recent study on interaction between ClO2 and protein, ClO2 oxidatively modified tyrosine and tryptophan residues, and the protein was structurally denatured. Since hemagglutinin and neuraminidase of influenza virus A/H1N1 were inactivated by the reaction with ClO2, it is likely that denaturation of the proteins caused inactivation of the virus. A low concentration (0.03 ppm) of ClO2 gas, where people can stay for a long period of time without any harmful effect, prevented the death of mice caused by infection of influenza virus delivered as aerosol. We review current information based on the efficiency of ClO2 solution and gas, and also discuss the application of ClO2 against influenza pandemics outbreak. - https://clinicaltrials.gov/ct2/show/NCT04343742: no results posted!
Brief Summary:Abstract The objective of this study is to review, through prospective case research, the efficacy of oral chlorine dioxide in the treatment of patients with COVID infection 19. The research will be carried out between April and June 2020 with a quasi-experimental design in two health care centers on a sample of twenty (20) patients, through direct intervention, who will measure the changes in the manifest symptoms of infection and negativity. a COVID 19 after administration of the study preparation, to determine the effectiveness of chlorine dioxide in the treated group.
Based on the results that are found and on the evaluation of efficacy on the basis of clinical improvement on a scale of 1 to 5, and of the negativization of COVID 19, we can conclude whether the therapeutic efficacy in this investigation is considered good by verifying whether or not there is efficacy of treatment with chlorine dioxide in COVID 19.
With this research, it is hoped to stimulate the search for new therapeutic options in the treatment of COVID 19 and contribute to the development of NEW options in medications, considering the immense number of deaths and morbidity that currently exists in the present pandemic. - https://www.researchgate.net/publication/315540771_Efficacy_and_Safety_Evaluation_of_a_Chlorine_Dioxide_Solution
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https://www.lifesolution.eu/studien: Das Ergebnis der Studie (Zitate ins deutsche Übersetzt): “Es wurden weder von den Teilnehmern, noch von dem untersuchenden Medizin-Team, ersichtliche, unerwünschte Schäden festgestellt“ und “Durch das Fehlen von schädlichen physiologischen Reaktionen, im Rahmen der Studie, wurde die relative Sicherheit von oraler Aufnahme von Chlordioxid und seinen Abbauprodukten bewiesen.“ (However, by the absence of detrimental physiological responses within the limits of the study, the relative safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and chlorate, was demonstrated. https://www.sciencedirect.com/science/article/abs/pii/S0272059081800425)