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Developmental or Reproductive Toxicity

In a study aimed at assessing thyroid function in neonates exposed directly to aqueous chlorine dioxide or potentially exposed in utero, groups of 15-18 Sprague-Dawley rat pups born to unexposed dams received 0 or 14 mg aqueous chlorine dioxide/kg body weight per day by oral gavage between days 5 and 20 post-partum. In addition, groups of 13-16 females received 0, 2, 20, or 100 mg aqueous chlorine dioxide/liter in drinking-water from 2 weeks prior to mating until pups were weaned (day 21 postpartum). Observations included food and water consumption, body weight, the age of eye opening, and locomotor activity. Terminal blood samples were taken from dams and pups for analysis of thyroid hormones T3 and T4. No clear information was presented on the general health of the dams (although body weight was apparently unaffected), making it difficult to determine the significance of any developmental effects in pups. Limited data were presented on body weight effects, although reduced body weight gain was noted for the pups born to chlorine dioxide-exposed dams between days 14 and 21 postpartum (50% lower between days 14 and 21). Locomotor effects were slight, variable, and transient, and hence of doubtful importance.

International Programme on Chemical Safety's Concise International Chemical Assessment Documents Number 37: Chlorine dioxide (2002). Available from, as of December 13, 2017: http://www.inchem.org/pages/cicads.html

 

(Rattenpups)

  • Hoeveelheid: 0 mg/kg body weight per day / Concentratie: 0 mg / liter
  • Hoeveelheid: 14 mg/kg body weight per day (1,15 x MMS-protocol) / Concentratie: onbekend.

 

(Vrouwtjesratten)

  • Hoeveelheid: 0 mg/kg body weight per day / Concentratie: 0 mg / liter 
  • Hoeveelheid: onbekend / Concentratie: 2 mg / liter (0,74x MMS-protocol)
  • Hoeveelheid: onbekend / Concentratie: 20 mg / liter (7,4x MMS-protocol)
  • Hoeveelheid: onbekend / Concentratie: 100 mg / liter (37,0x MMS-protocol)

 

Commentaar CLO2.nl: HEEL interessant!

  • rattenbabies 14 mg/kg body weight per day. Dat zijn waarden die je kunt vergelijken met het MMS-protocol in Oeganda.
  • 0, 2, 20, or 100 mg ClO2/liter in drinking-water, dan praat je over waarden die veel veiliger/lager zijn dan MMS-protocollen.
  • Het resultaat: verwaarloosbare verschillen.