1985: /GENOTOXICITY/ Groups of five male and five female CD-1 mice received five daily oral gavage doses of approximately 0, 5, 10, or 20 mg aqueous chlorine dioxide/kg body weight. animals were killed 6 hr after the last administration, and 1000 polychromatic erythrocytes from the bone marrow of each animal were analyzed for micronucleus formation. In addition, groups of four male and four female CD-1 mice were used for analysis of chromosome aberrations from bone marrow samples. Animals were exposed to the same doses as above, either as a single administration or using a repeated-exposure regime. Following single exposure, animals were killed at 6, 24, and 48 hr post-administration and 50 metaphase cells taken from the bone marrow of each animal for analysis of chromosome aberrations. A negative result was obtained for micronucleus formation, and there were no increases in the number of structural or numerical chromosome aberrations (including an assessment of hyperploidy and polyploidy).
International Programme on Chemical Safety's Concise International Chemical Assessment Documents Number 37: Chlorine dioxide (2002). Available from, as of December 13, 2017: https://www.inchem.org/documents/cicads/cicads/cicad37.htm#8.6.3
Commentaar CLO2.nl: HEEL interessant!
- 5, 10, or 20 mg aqueous chlorine dioxide/kg body weight, dat zijn hoeveelheden die corresponderen met het Oeganda.
- Geen effect gemeten!